Tested like a drug.
Worked like food.
A randomized controlled clinical trial conducted at Mayo Clinic and the University of Manitoba — published in The Journal of Nutrition.
Highest LDL cholesterol reduction in 30 days
Of participants saw measurable LDL reduction
To meaningful, measurable change
Adherence rate — unprecedented in nutrition trials
A real-world test
Most nutrition studies are weak — short, observational, or done on captive populations eating provided meals. Ours wasn't.
Participants in our randomized, double-blind, crossover trial lived their normal lives. They cooked, traveled, ate out, and substituted Step One Foods products twice a day for foods they were already eating — no other dietary or lifestyle changes required.
The control group ate matched "healthy" foods without the active ingredient profile. Step One Foods produced significantly greater LDL reductions than the active healthy control — the strongest possible evidence that the formulation, not just "eating healthier," is what works.
Why these results matter
Even an 8.8% LDL reduction is very clinically meaningful — and expected to be associated with significant risk reduction as based on a mountain of existing published data. Making these foods a good choice for anyone with elevated cholesterol readings.
Some participants achieved 20%, 30%, even nearly 40% LDL reductions in just 4 weeks — comparable to what's expected with prescription medication. For people who can't tolerate statins, don't want to take them, or aren't reaching their LDL goal despite maximum tolerated medical therapy, that's a potential game changer.
And critically: 95% of participants stayed on the program. Compare that to typical diet-trial adherence in the 30–50% range. Adherence is what separates a study from a real solution.
Read the published study in The Journal of NutritionValidated at institutions known for excellence.
We didn't partner with just any lab. Our research was conducted at two of the most respected institutions in their respective fields.
Mayo Clinic
Excellence in Patient Care
Consistently ranked the #1 hospital in America by U.S. News & World Report, the Mayo Clinic is synonymous with clinical excellence. Our randomized, controlled trial was conducted here — applying the same rigor used for pharmaceutical development to a food product.
University of Manitoba
World Leader in Nutrition Research
Home to the Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), the University of Manitoba is globally recognized for its contributions to functional food and nutraceutical research. Their expertise in lipid metabolism and dietary bioactives is unmatched.
See what the science feels like.
Try the 30-Day Clinical Trial Pack — the same protocol used in the trial.
Get the Clinical Trial Pack